POS1158 THE SPECTRUM OF NON-TUBERCULOUS OSTEOARTICULAR INFECTIONS IN A RHEUMATOLOGY DEPARTMENT DURING THE YEARS 2010-2020: A RETROSPECTIVE STUDY OF 102 CONSECUTIVE CASES IN A SINGLE CENTER

Background: osteoarticular infections (OAI) are characterized by a large variety of sites, causative microorganisms, source and route infection, risk factors also the fact that several medical specialties involved in diagnosis treatment. These characteristics subject to changes over time. Objectives: describe spectrum non-tuberculous OAI absence OA material, including native septic arthritis (SA) non-postoperative SA or infectious spondylodiscitis (SPDI) during years 2010-2020. This includes demographics, comorbidities, site diagnosis, treatment procedures mortality. Methods: records patients aged 18 old above who were diagnosed with Department rheumatology our hospital 2010-2020 period selected retrospectively reviewed. following excluded: on prosthetic joints, postoperative SPDI, osteomyelitis, brucellosis, Lyme disease. Only proven cases where included basis an isolated pathologic organism at infection and/or blood (with typical clinical, biological imaging features). Results: There 102 consecutive (males 62%), 62.5±16.8 years, IMC 25.1±5.2. Peripheral observed 52 cases, SPDI 33 non-peripheral 10 (sacroiliitis 5, pubic symphysitis 2, sternoclavicular posterior interapophyseal 1); 7 patients, there was association peripheral SA. At least two non-contiguous sites 22 (21.5%). The positive sample where: (synovial fluid, vertebral biopsy) 47 cases; 28 both them 27 cases. In 105 microorganisms grew culture one Candida glabrata. bacteria responsible other cases: 42 Staphylococcus aureus (including 3 methicillin resistant); coagulase-negative spp.; 6 Group A Streptococcus ; 12 group B agalactiae 8 groups C/G D gallolyticus 2 pneumoniae 1 Neisseria gonorrhea enterobacteria; Enterococcus faecalis; Pseudomonas aeruginosa Haemophilus others species (2 Parvimonas micra , aerococcus urinae Nesseiria bacilliformis bacteroides fragilis campylobacter fetus ). most frequent host were: diabetes (21%), inflammatory/auto-immune disease (10%; rheumatoid arthritis), chronic renal insufficiency (CC<30 ml/mn) (6%), active cancer local general extension immunodeficiency state (SCID revealed cases). Three therapy. known 76 skin 27; urinary tract 17; joint injection dental infected vascular material abdominal 5 genital ENT pulmonary Mean duration symptoms ranged from 13 days for 39 SPDI. Fever (≥38°C) present 52% CRP 182±128 mg/l. Blood cultures 55.5%. only case endocarditis. All treated antibiotics mean 10.2±5.6 weeks. Orthopedic surgery proceeded 67% 10% OAI. Six admitted intensive care unit; 4 died (4.3%). length hospitalization 28.6±15 days. Conclusion: 2010-2020, represents regular cause rheumatology. Iatrogenic origin accounts 13% 17%. 48% Streptococcal 30%. Disclosure Interests: None declared.